Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

"Cet ouvrage propose de souligner le passage de l’être à la lettre en mettant l’accent sur la rupture avec l’ontologie. Il décrit le mouvement allant de l’un à l’autre dans une sorte de « séparation liante » (AHN, p. 185) qui n’implique guère de reniement – ni d’un côté ni de l’autre. Il ne propose pas de synthèse, mais une autre distribution d’accents. Dans un premier temps, l’auteur s’interroge : cette façon de penser conduit-elle Levinas « hors du champ de (...) la philosophie »? Puis il met Levinas « à l’épreuve de l’autre », en le confrontant – toujours à partir de la perspective judaïque – à des auteurs tel que Rosenzweig sur les questions de l’éducation, Meschonnic sur la modalité du sacré, Blanchot sur l’être Juif, Janicaud au sujet du tournant théologique qu’il aurait imprimé à la phénoménologie, ou encore Benny Lévy sur l’attachement marqué de Levinas au « grec », à savoir à la philosophie. Toutefois, l’originalité de l’ouvrage réside dans la comparaison à des auteurs beaucoup moins connus dans notre espace européen : à Leibovitz pour lequel le judaïsme est une « religion revendicative », assignant l’humain aux commandements ; à Israël Salanter – fondateur du Moussar à Kovno, en Lituanie ; au rav Soloveitchik sur la question de la halakha. Mais aussi à un penseur étonnant et tonique, Daniel Epstein qui nous a livré, en hébreu, une présentation magistrale, précise et en nuances."-- page 4 de couverture. (shrink)

Perhaps the best way to understand Harold Bloom's enigmatic theory of "poetic misprision" is to avoid the immanent critique altogether. It is best described, rather , as a synthesis. Bloom seems to have taken Aristotle's mimesis and linked it to Freud's concept of sublimation,1 with particular emphasis on the role that sublimation plays in "the family romance." Even if one were to hedge a bit and take into account the fact that neo-Freudian re-evaluations of orthodox psychoanalysis have succeeded in extracting (...) the purely sexual component out of the psychodynamics of sublimation, one is still left with the notion of sublimation as anxiety producing. Thus it is that, according to Bloom, the modern poet, in particular, sublimates his imitation of a strong precursor poet. Since the emphasis today is on desexualizing libido, Freud's original sexual vocabulary seems to have survived for its metaphorical value alone; the "unconscious fear of castration," for example, is simply a metaphor for "the poet's fear of ceasing to be a poet," a man's fear of ceasing to be a man. No matter how much we "modernize" Freud, the fact will always remain that the psychoanalytic context is the context of psychopathology: "a variety of the uncanny." · 1. See Sigmund Freud, Three Contributions to the Theory of Sex, in The Basic Writings of Sigmund Freud, ed. and trans. A. A. Brill , pp. 625-26. David D. Cooper is an associate in the department of English at the University of California, Santa Barbara. Using the critical paradigm developed in the present essay, he has written a book on Thomas Merton's poetry. See also: "Poetry, Revisionism, Repression" by Harold Boom in Vol. 2, No. 2; "Formalism, Savagery, and Care; or, The Function of Criticism Once Again" by Jerome J. McGann in Vol. 2, No. 3. (shrink)

Constructivism is based on the principle that our personalities, behavior, and society are organized by the ways in which we attribute meanings to events, and act upon those meanings. It provides a philosophy, an epistemology, and methods that are especially congruent with the central values of social work, particularly client self-determination. In this volume, Dr. David D.V. Fisher introduces social workers to constructivism, a perspective which is becoming increasingly popular in the social sciences, and which has already been embraced (...) by clinical psychologists, communication researchers, and cyberneticians. Fisher explains constructivism as an epistemology, shows the consequences of adopting a constructivist epistemology in contrast to operating from within the traditional objectivist epistemology, demonstrates the ethical appropriateness and practicality of constructivism for social work, and explicates a number of specific applications of constructivism to social work. The book is divided into two parts. The first part consists of an introduction and then explains and expands the theory of constructivism and its relationship to social work. The second part shows how constructivist principles may be applied in social work practices. Constructivist principles are applied to selected aspects of assessment, intervention, and interviewing--using immediate experience as a guide to action and the creation of professional responsibility. An Introduction to Constructivism for Social Workers will be of particular interest to social workers and psychologists involved in theory and research. (shrink)

When The Absurd Hero in American Fiction was first released in 1966, Granville Hicks praised it in a lead article for the Saturday Review as a sensitive and definitive study of a new trend in postwar American literature. In the years that followed, David Galloway’s analysis of the writings of John Updike, William Styron, Saul Bellow, and J. D. Salinger became a standard critical work, an indispensable tool for readers concerned with contemporary American literature. The New York Times described (...) the book as “a seminal study of the modern literary imagination." David Galloway, himself an established novelist, later extensively revised The Absurd Hero to include authoritative discussions of more than a dozen novels which had appeared since the first revised edition was released in 1970. Among them are John Updike’s Couples, Rabbit Redux, and The Coup; William Styron’s The Confessions of Nat Turner and Sophie’s Choice; and Saul Bellow’s Mr. Sammler’s Planet and Humboldt’s Gift. Through detailed analyses of these works, Galloway demonstrates the continuing relevance of his own provocative concept of the absurd hero and provides important insights into the literary achievements of four of America’s most influential postwar novelists. (shrink)

Nikon D40/D40x Digital Field Guide is filled with everything you need to know in order to take amazing photographs using your Nikon D40 or Nikon D40x. This full-color portable guide walks you through the essential controls, features, and functions of your Nikon D40 or D40x digital SLR using step-by-step instructions and full-color images of each menu screen. This robust guide not only shows you how to adjust white balance, autofocus, exposure, and choose lenses, it also teaches you when and why (...) you should adjust each of these key settings. The Nikon D40/D40x Digital Field Guide goes beyond camera settings to offer you a refresher guide to the principles of digital photography, covering the essentials of lighting, composition, and exposure. Filled with amazing examples, this book also presents you with a variety of tips and tricks to capturing portraits, candids, sports, travel, macro photography, and much more. (shrink)

This article assesses Herman Paul's intellectual biography of Hayden White, the most important figure in the philosophy of history of the past half century. Offering a clear overview of White's career and contribution, Paul's account proceeds chronologically from the 1950s to the present, distinguishing the phases of White's career, but convincingly pinpointing an abiding core of concerns around an existentialist and liberationist humanism. In that light, White sought to show the way beyond historiographical realism to more innovative approaches—ideally to serve (...) progressive politics. Paul notes, however, that White failed to connect with most mainstream historians, and Paul's account is not sufficiently probing and critical to explore the gulf. Indeed, following White, Paul is too prone to take White's particular liberationist agenda as the only alternative to a conservative, passive realism—and thereby to gloss over alternative ways of conceiving the postrealist cultural space. Moreover, Paul fails to note White's tendency sometimes to imply that mainstream history claims more than it does, and sometimes to denigrate prejudicially what it in fact does, or could do. Although much of White's challenge could have been especially salutary, he tended toward mischaracterizations that fostered polarization in the historical discipline and reinforced prejudicial understandings of historiography in the wider culture. Paul's overview provides a useful, and in many ways exemplary, introduction to White's legacy, but it is too deferential to provide a convincing overall critical assessment. (shrink)

Explains how to set up a digital photography studio, improve picture-taking techniques, edit images, use Photoshop and Photoshop Elements, restore photographs, and print and distribute digital images.

Physicians and other healthcare professionals are increasingly finding ways to use artificial intelligent decision support systems in their work. IBM Watson Health, for example, is a commercially available technology that is providing AI-DDS services in genomics, oncology, healthcare management and more.1 AI’s ability to scan massive amounts of data, detect patterns, and derive solutions from data is vastly more superior than that of humans. AI technology is undeniably integral to the future of healthcare and public health, and thoughtful consideration of (...) the legal, ethical and moral issues surrounding this technology is a must. The authors of the article, Responsibility, Second Opinions, and Peer-Disagreement—Ethical and Epistemological Challenges of Using AI in Clinical Diagnostic Contexts, provide an informed discussion of how AI-DSS may be used, both practically and ethically, to assist healthcare professionals in cooperative diagnostic processes2. The authors propose a process, whereby AI-DSS would provide a physician a second opinion, and when there is a mismatch between opinions, another physician would provide a third opinion. This approach maintains a ‘physician-in-charge’ perspective, and suggests that decision-making must ultimately be made by a person. This approach is also consistent with the ‘physician in-the-loop’ concept, such that even when increasingly autonomous AI-DSSs are put to use, physicians will still be providing checks and overseeing clinical decisions. The authors conceptualise AI as a replacement of human cognitive labour. That is, AI is used to supplant a human professional in particular functions …. (shrink)

A fascinating collection of revealing memoirs by sixty-four philosophers discussing how they fell in love with philosophy, their calling to this life in pursuit of wisdom, and how they eventually or suddenly became philosophers.

Provides information on using digital SLR cameras, covering such topics as memory cards, choosing exposure, lenses, using RAW files, using the flash, composing a photograph, and image editing.

For the past two decades, the humanistic disciplines have been dominated by poststructuralist theories and, more recently, a not unrelated curricular philosophy best defined as hardline multiculturalism, much discussed and often misunderstood. When linked together, they form an internal contradiction that is the moral challenge of liberal education today. Traditional political alignments cannot explain current divisions among the humanities professoriate. Ideological quarrels only obscure a deeper moral debate between an ascendant poststructuralism and a resurgent liberal humanism. It is important to (...) reappropriate liberal humanism in an effort to revitalize humanistic inquiry and renew its place in creative public discourse, and check a danger posed by poststructuralism's fascination with power and epistemological relativism which threaten to erase the ethical border between education and indoctrination. (shrink)

No writer or public intellectual of our era has been as sensitive to the role of faith in the lives of ordinary Americans as Robert Coles. Though not religious in the conventional sense, Coles is unparalleled in his astute understanding and respect for the relationship between secular life and sacredness, which cuts across his large body of work. Drawing inspiration from figures like Dietrich Bonhoeffer, Dorothy Day, and Simone Weil, Coles’s extensive writings explore the tug of war between faith and (...) doubt. As Coles himself admits, the “back-and-forthness between faith and doubt is the story of my life.” These thirty-one thought-provoking essays are drawn from Coles’s weekly column in the Catholic publication _America_. In them, he turns his inquisitive lens on a range of subjects and issues, from writers and painters to his recent reading and film viewing, contemporary events and lingering controversies, recollections of past and present mentors, events of his own daily life, and ordinary encounters with students, patients, neighbors, and friends. Addressing moral questions openly and honestly with a rare combination of rectitude and authorial modesty, these essays position Coles as a preeminent, durable, and trusted voice in the continuing national conversation over religion, civic life, and moral purpose. (shrink)

ABSTRACT In The Longing for Total Revolution, Bernard Yack claims not to account for totalitarianism but simply to unearth a new, specifically modern mindset. Still, the problem of totalitarianism, and whatever connection it might have had with that mindset, lurks throughout his book. Yack convincingly posits a relationship between a troubling new sense of historical embeddedness and novel totalist thinking. But his sense of the range of responses to historicity proves too limited to illuminate the connection between the longing for (...) total revolution and the advent of totalitarianism. Another look at Yack’s two culminating figures, Marx and Nietzsche, suggests a more illuminating alternative. (shrink)

Political science faces a challenge from a “Mr. Perestroika,” who decries the hegemony of formal and statistical analysis in the discipline. Although not connected with this movement, Bent Flyvbjerg makes the best case for a renewed dominance for qualitative and case study work throughout the social sciences. This article challenges Flyvbjerg’s call for a phronetic as opposed to an epistemic discipline. It challenges as well the unqualified call for pluralism advocated by many in the perestroika movement. It offers instead an (...) integrated tripartite method in which narrative, statistics, and formal modeling fill in a scientific frame. (shrink)

Christian Exegesis of the Qurʾān: A Critical Analysis of the Apologetic Use of the Qurʾān in Select Medieval and Contemporary Arabic Texts. By J. Scott Bridger. American Society of Missiology Monograph Series, vol. 23. Eugene, OR: Wipf and Stock, 2015. Pp. xii + 188. $25.

For a patient to make an informed decision about participation in research, it is fundamental that they can understand what is involved. COREC has produced a model information sheet and consent form that researchers are encouraged and sometimes forced to use by LRECs. By applying readability statistics to these documents we have shown that the majority of the UK population would not be able to read this proposed text.