Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

"Cet ouvrage propose de souligner le passage de l’être à la lettre en mettant l’accent sur la rupture avec l’ontologie. Il décrit le mouvement allant de l’un à l’autre dans une sorte de « séparation liante » (AHN, p. 185) qui n’implique guère de reniement – ni d’un côté ni de l’autre. Il ne propose pas de synthèse, mais une autre distribution d’accents. Dans un premier temps, l’auteur s’interroge : cette façon de penser conduit-elle Levinas « hors du champ de (...) la philosophie »? Puis il met Levinas « à l’épreuve de l’autre », en le confrontant – toujours à partir de la perspective judaïque – à des auteurs tel que Rosenzweig sur les questions de l’éducation, Meschonnic sur la modalité du sacré, Blanchot sur l’être Juif, Janicaud au sujet du tournant théologique qu’il aurait imprimé à la phénoménologie, ou encore Benny Lévy sur l’attachement marqué de Levinas au « grec », à savoir à la philosophie. Toutefois, l’originalité de l’ouvrage réside dans la comparaison à des auteurs beaucoup moins connus dans notre espace européen : à Leibovitz pour lequel le judaïsme est une « religion revendicative », assignant l’humain aux commandements ; à Israël Salanter – fondateur du Moussar à Kovno, en Lituanie ; au rav Soloveitchik sur la question de la halakha. Mais aussi à un penseur étonnant et tonique, Daniel Epstein qui nous a livré, en hébreu, une présentation magistrale, précise et en nuances."-- page 4 de couverture. (shrink)

Physicians and other healthcare professionals are increasingly finding ways to use artificial intelligent decision support systems in their work. IBM Watson Health, for example, is a commercially available technology that is providing AI-DDS services in genomics, oncology, healthcare management and more.1 AI’s ability to scan massive amounts of data, detect patterns, and derive solutions from data is vastly more superior than that of humans. AI technology is undeniably integral to the future of healthcare and public health, and thoughtful consideration of (...) the legal, ethical and moral issues surrounding this technology is a must. The authors of the article, Responsibility, Second Opinions, and Peer-Disagreement—Ethical and Epistemological Challenges of Using AI in Clinical Diagnostic Contexts, provide an informed discussion of how AI-DSS may be used, both practically and ethically, to assist healthcare professionals in cooperative diagnostic processes2. The authors propose a process, whereby AI-DSS would provide a physician a second opinion, and when there is a mismatch between opinions, another physician would provide a third opinion. This approach maintains a ‘physician-in-charge’ perspective, and suggests that decision-making must ultimately be made by a person. This approach is also consistent with the ‘physician in-the-loop’ concept, such that even when increasingly autonomous AI-DSSs are put to use, physicians will still be providing checks and overseeing clinical decisions. The authors conceptualise AI as a replacement of human cognitive labour. That is, AI is used to supplant a human professional in particular functions …. (shrink)

Controversy has long surrounded the complex relationship between King Victor Emmanuel III and the dictator Benito Mussolini in Fascist Italy. It is clear that the king played decisive roles in bringing Mussolini to power in 1922 and in removing him in 1943. In between, the two coexisted as Italy became a ‘dyarchy’, with two foci of power. The presence of the monarchy at once checked Fascist radicalism and persuaded many conservatives to adhere to the regime. Thanks especially to the monarchy, (...) the innovative thrust of Fascism was channelled in certain delimited directions, toward a statist economy, for example. Still, the relationship between the crown and Mussolini was often rocky, though the king’s reluctance did not prevent alliance with Nazi Germany, anti-Semitism, and war. Tensions were largely papered over by rhetoric and myth-making, as if the elements of Fascism fit together neatly. Despite his opposition to certain particulars, Victor Emmanuel identified with the overall Fascist project to some extent, and he worried that outright opposition to the regime would jeopardize the monarchy. But as the Second World War went badly for Italy, the king finally deposed Mussolini. Nevertheless, Italy soon voted to eliminate the monarchy, discredited by its association with fascism. (shrink)

An alternative approach to emotion is presented here, which differs from that of Kagan and others. It orders emotion along a continuum of the embodiment of emotion, starting with a clear but rare case of pure emotion and at the other extreme discusses Damasio’s intelligent prefrontal patients who could not feel emotions critical to social life.

Sie halten stolz Ihre neue digitale Kamera in den Händen und würden damit gerne alles übertreffen, was Sie jemals an Fotos geschossen haben? Mit Digitale Fotografie für Dummies XXL-Edition ist das kein Problem! David D. Busch gibt Ihnen nicht nur einen Überblick über die Möglichkeiten der neuen Kameratechnik, sondern steigt mit Ihnen tief und Schritt für Schritt in alle Bereiche ein, die für ein gutes Foto wichtig sind. Angefangen vom Equipment über die richtige Aufnahmetechnik bis hin zur Bearbeitung am (...) Computer und der Ausgabe im Druck oder Internet bleiben keine Fragen offen. Machen Sie die digitale Fotografie zu Ihrem Lieblingshobby und genießen Sie nachher die beeindruckenden, professionellen Ergebnisse! (shrink)

For a patient to make an informed decision about participation in research, it is fundamental that they can understand what is involved. COREC has produced a model information sheet and consent form that researchers are encouraged and sometimes forced to use by LRECs. By applying readability statistics to these documents we have shown that the majority of the UK population would not be able to read this proposed text.

Ensuring that research is of high quality and is based on sound ethical principles is not easy; it requires a fine balance between adequate oversight and suitable facilitation. The current state of research ethics governance is an ideal environment to maintain a governance ‘ratchet’ rather than produce a well-organized and carefully thought out ‘dial’.

Explains how to set up a digital photography studio, improve picture-taking techniques, edit images, use Photoshop and Photoshop Elements, restore photographs, and print and distribute digital images.

Provides information on using digital SLR cameras, covering such topics as memory cards, choosing exposure, lenses, using RAW files, using the flash, composing a photograph, and image editing.

A fascinating collection of revealing memoirs by sixty-four philosophers discussing how they fell in love with philosophy, their calling to this life in pursuit of wisdom, and how they eventually or suddenly became philosophers.

When The Absurd Hero in American Fiction was first released in 1966, Granville Hicks praised it in a lead article for the Saturday Review as a sensitive and definitive study of a new trend in postwar American literature. In the years that followed, David Galloway’s analysis of the writings of John Updike, William Styron, Saul Bellow, and J. D. Salinger became a standard critical work, an indispensable tool for readers concerned with contemporary American literature. The New York Times described (...) the book as “a seminal study of the modern literary imagination." David Galloway, himself an established novelist, later extensively revised The Absurd Hero to include authoritative discussions of more than a dozen novels which had appeared since the first revised edition was released in 1970. Among them are John Updike’s Couples, Rabbit Redux, and The Coup; William Styron’s The Confessions of Nat Turner and Sophie’s Choice; and Saul Bellow’s Mr. Sammler’s Planet and Humboldt’s Gift. Through detailed analyses of these works, Galloway demonstrates the continuing relevance of his own provocative concept of the absurd hero and provides important insights into the literary achievements of four of America’s most influential postwar novelists. (shrink)

For the past two decades, the humanistic disciplines have been dominated by poststructuralist theories and, more recently, a not unrelated curricular philosophy best defined as hardline multiculturalism, much discussed and often misunderstood. When linked together, they form an internal contradiction that is the moral challenge of liberal education today. Traditional political alignments cannot explain current divisions among the humanities professoriate. Ideological quarrels only obscure a deeper moral debate between an ascendant poststructuralism and a resurgent liberal humanism. It is important to (...) reappropriate liberal humanism in an effort to revitalize humanistic inquiry and renew its place in creative public discourse, and check a danger posed by poststructuralism's fascination with power and epistemological relativism which threaten to erase the ethical border between education and indoctrination. (shrink)

Unlike the memory of the querulous and time-bending White Queen inThrough the Looking Glass, mine befits her complaint, inclined as I am to thinking backwards when asked to contemplate the state of our field. Backwards, then, I go in the first section of this essay, after a few opening comments on the situation of our field at the present moment. Thereafter, I describe the emergence of cultural history and summarize some of its strengths and weaknesses, to the end of reflecting (...) on its implications for intellectual history. (shrink)

_Draws out numerous affinities between the sophists and Socrates in Plato's dialogues._.

Your digital camera is the perfect travel companion. You don't need to pack extra film, worry about airport scanners, budget for processing costs, or wait until you get home to learn whether you got that once-in-a-lifetime shot. Tuck this book in beside your Frommer's travel guide and you'll have everything you need for fantastic photos-how to watch for the right opportunity, compose the picture, work with lighting-even how to edit and upload from the road. * Learn what you must take (...) along and which accessories are nice to have * Capture the soul of a city, its people, and its sights * Include fellow travelers without shooting stereotypes * Take great shots even where flash is prohibited or your light sources are limited * Explore scenarios and expert tips for photographing scenery, wildlife, events, exhibits, and much more * Post your photos on the Web before you get home. (shrink)

Describes the features of the Sony Alpha DSLR-A100 camera, with information on such topics as exposure, lighting, lenses, composition, landscape photography, panoramic photography, and editing pictures.

There are presently two modern critical editions of Proclus' commentary on the Parmenides. One, the edition of the Oxford Classical Texts, was completed under the auspices of Carlos Steel in 2009. The other, the Budé edition, under the editorship of Concetta Luna and the late Alain-Philippe Segonds, followed soon after, with the third of the first three books of the commentary having appeared in the early 2012. This most recent two-part volume of the Budé addresses, for the final time it (...) seems, the Budé's criticisms of the OCT edition. The first volume could be well described as a long philippic against the OCT and its editor and contributors, going well beyond the tone of measured academic discourse. Relentlessly, it imprecates the readings of the OCT, the length and tone of which criticisms will not weather time well. However, there is one disagreement between the two editions, perhaps the most textually significant one and certainly the largest, which is noted as a part of a comprehensive list by the Budé, but no discussion ensues. This is all the more curious because Steel had, in a separate article, directly raised objections to their solution to this passage. Why in this single case is the Budé suddenly so taciturn? (shrink)

This article assesses Herman Paul's intellectual biography of Hayden White, the most important figure in the philosophy of history of the past half century. Offering a clear overview of White's career and contribution, Paul's account proceeds chronologically from the 1950s to the present, distinguishing the phases of White's career, but convincingly pinpointing an abiding core of concerns around an existentialist and liberationist humanism. In that light, White sought to show the way beyond historiographical realism to more innovative approaches—ideally to serve (...) progressive politics. Paul notes, however, that White failed to connect with most mainstream historians, and Paul's account is not sufficiently probing and critical to explore the gulf. Indeed, following White, Paul is too prone to take White's particular liberationist agenda as the only alternative to a conservative, passive realism—and thereby to gloss over alternative ways of conceiving the postrealist cultural space. Moreover, Paul fails to note White's tendency sometimes to imply that mainstream history claims more than it does, and sometimes to denigrate prejudicially what it in fact does, or could do. Although much of White's challenge could have been especially salutary, he tended toward mischaracterizations that fostered polarization in the historical discipline and reinforced prejudicial understandings of historiography in the wider culture. Paul's overview provides a useful, and in many ways exemplary, introduction to White's legacy, but it is too deferential to provide a convincing overall critical assessment. (shrink)

ABSTRACT In The Longing for Total Revolution, Bernard Yack claims not to account for totalitarianism but simply to unearth a new, specifically modern mindset. Still, the problem of totalitarianism, and whatever connection it might have had with that mindset, lurks throughout his book. Yack convincingly posits a relationship between a troubling new sense of historical embeddedness and novel totalist thinking. But his sense of the range of responses to historicity proves too limited to illuminate the connection between the longing for (...) total revolution and the advent of totalitarianism. Another look at Yack’s two culminating figures, Marx and Nietzsche, suggests a more illuminating alternative. (shrink)

Despite suggestions that the end of metaphysics leaves us with nothing but history, essential questions about the place of history in a post-metaphysical culture have been neglected. In one sense history "weakens" as the scope for "realism" or a teleological master narrative fall away. But it invites overreaction to suggest that history becomes a "process of weakening" insofar as things have come to be as they are not as the resultants of full, meaningful origins, but only through the "dread accident" (...) of the historical process. The world that has resulted from history is the only one we have, and it weighs on us; in that sense history does not weaken but strengthens. Still, the historical process enveloping us is not Hegelian and necessary but weak and contingent, its outcomes subject to further contest. Conversely, although truth is weak, finite, and provisional, it is not merely consensual or relative precisely because it is historical. To grasp the sense it which history both weakens and strengthens enables us to grasp the scope for learning more deeply from our historical experience. A fuller range of historical questions about modernity would enable us better to understand the ongoing dangers and possibilities of modern politics. (shrink)

Christian Exegesis of the Qurʾān: A Critical Analysis of the Apologetic Use of the Qurʾān in Select Medieval and Contemporary Arabic Texts. By J. Scott Bridger. American Society of Missiology Monograph Series, vol. 23. Eugene, OR: Wipf and Stock, 2015. Pp. xii + 188. $25.